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Mass Spectrometry in Drug Discovery, Proteomics, and Metabolomics

August 26th and 27th, 2006

Who Should Attend

Anyone seeking an introduction to the field of mass spectrometry its instrumentation and its application to proteomics, metabolomics, and drug discovery. A general understanding of a mass spectrometry is helpful. Typical attendees include scientists, engineers, lab managers, marketing and sales professionals, and students.

Course Goals

  • Learn about the most recent technology developed for proteomics, metabolomics, PK-ADME analysis, and drug discovery
  • Obtain a basic understanding of ionization and mass analysis
  • Learn why mass spectrometry is one of the most important tools in biology and chemistry
  • Learn the methods of generating data from mass spectrometers
  • Approaches to data analysis for protein identification and characterization
  • Become aware of quantitative analysis for both small molecule metabolites and proteins
  • Learn the advantages and limitations of this technology for these specific applications

Course Topics

  • Ionization approaches for biological and chemical screening
  • Pharmacokinetics/metabolite profiling and quantitation methods
  • Protein identification with MALDI-MS and LC/MS/MS
  • Multidimensional LC/MS/MS analysis for complex protein analysis
  • Computational approaches to data analysis for identification and quantitative analysis
  • Approaches to drug discovery through surface-based mass spectrometry
  • Approaches to drug discovery through monitoring noncovalent interactions
  • Mass analysis approaches for biological and chemical screening
  • Computational approaches for data analysis and acquisition
  • High throughput applications of mass spectrometry

Course Instructors

Mike Greig (Michael.Greig@pfizer.com) has led the Discovery Technologies Mass Spectrometry group at Pfizer Global R&D - La Jolla Laboratories since 1997. Prior to that, he worked at Revlon Science Institute (La Jolla, CA) working as a polymer and analytical chemist and at Isis Pharmaceuticals (Carlsbad, CA) as the Mass Spectrometry Lab Manager. He has over 13 years experience in the field of mass spectrometry and analytical chemistry, analyzing everything from small molecules to polymers to proteins. He has taught mass spectrometry classes at various scientific conferences around the world, is a member of the Lab Automation Scientific Committee, and has over 40 presentations and publications. Specific expertise in high throughput MS systems, software and analysis, oligonucleotide analysis, SFC/MS and LC/MS, FTICR-MS, APPI, and general mass spectrometry.

Gary Siuzdak (siuzdak@scripps.edu), is Senior Director of the Center for Mass Spectrometry at The Scripps Research Institute where he is also Associate Professor of Molecular Biology. He is the founder of Mass Consortium Corporation (1994), organizer of the San Diego Mass Analysis Network since its inception in 1995, and has written two books Mass Spectrometry for Biotechnology (1996, Academic Press) and The Expanding Role of Mass Spectrometry in Biotechnology (2003, MCC Press). Dr. Siuzdak has over 110 peer-reviewed publications and his research has focused on biochemical applications of mass spectrometry.
For more information see http://masspec.scripps.edu.

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